Abstract
Summary
AY-9944, an orally active inhibitor of cholesterol biosynthesis, caused in rats, pigs and dogs greatly reduced serum cholesterol levels, only partly compensated by 7-dehydrocholesterol formed instead of cholesterol by the action of AY-9944. The distribution of 7-dehydrocholesterol between serum lipoprotein fractions differed from cholesterol and varied from species to species. Levels of 7-dehydrocholesterol and their distribution may reflect the rate of sterol biosynthesis.
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