Abstract
Summary
When Simian adenovirus Type 15 was heated at 50°C in the presence of 1M MgCl2, it was found that inactivation of the virus infectivity was dependent upon the pH of the test medium. Dilution of dialyzed virus in 0.05M L-histidine buffer at pH 5.0 or 5.4 resulted in no inactivation of the virus following 2 hours' heating at 50°C in 1M MgCl2; however, virus inactivation increased in response to an increase in pH from 5.7 to 6.9 under the same test conditions.
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