Abstract
Summary
Rats pretreated with human serum albumin aggregate (10-20 mμ) develop significant stimulation of total RES phago-cytic capacity without appreciable increase in RES organ masses. Such pretreated animals show significantly increased survival after traumatic, intestinal ischemia and endotoxin shock but not after hemorrhage. Since RES mediated mechanisms have been implicated in both the pathogenesis of and adaptive resistance to shock, experimental manipulation of the RES by other than the frankly toxic materials used heretofore suggests a potentially compatible approach to prophylactic shock therapy.
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