Studies on a Murine Lymphoma Induced by Reovirus Type 3

Abstract

Summary

Preliminary studies on a murine lymphoma induced by neonatal infection with reovirus type 3 are reported. In the mature animal, the lymphoma has a restricted host range while in the neonate such restriction does not operate. The development of lymphoma is associated with the intact primitive living lymphoblastic cell which has a definite storage time. All attempts to isolate a murine leukemia virus have proved unsuccessful as have attempts to locate complete infectious reovirus type 3. The organ distribution of the lymphoma and some associated immuno-logical features are discussed with consideration of a possible relationship to Burkitt's African lymphoma.