Abstract
Summary
A method has been described to demonstrate leukocytic responses in the peritoneal cavity of mice to challenge substances, which uses quinacrine to label the leukocytes for fluorescent microscopy. The leukocyte reaction to intraperitoneally inoculated Ehrlich ascites tumor cells was observed to be decreased in the presence of an already established ascites tumor. Massive tumor inoculation (6 cc EAT intraperitoneally) appears to suppress the outpouring of leukocytes in an immediate fashion, although a response does occur when turpentine is administered concomitantly. One explanation for these observations is the alteration of host defenses by the neoplastic cells.
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