Abstract
Summary
1. The activity against M yco-bacterium leprae of 4,4-diaminodiphenyl sul-fone (DDS) was tested in mice by feeding a series of diets containing the drug in concentrations ranging from 0.03 to 0.00001%. Multiplication of M. leprae was completely suppressed at all levels. 2. The lowest DDS intake was a hundred times less that the least amount required to produce chemically detectable amounts in the blood (0.2 to 0.3 μg/ml).
Get full access to this article
View all access options for this article.