Abstract
Summary
The inhibitory effect of cysteine in the S. griseus phage-host system involved a sulfhydryl effect, which at a concentration of 50 μg/ml caused a 75% decrease in phage yield. A relatively short exposure time of 20 minutes during the early portion of the latent period was sufficient to produce near maximum inhibition. Presence of homoserine, methionine, threonine, or isoleucine did not alleviate the effect. The data obtained favor an interference mechanism whereby phage protein biosynthesis is inhibited through disulfide bond cleavage.
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