Abstract
Summary
Ectopic calcification of the aortas of rats was induced by large doses of vit D3. The calcification was accompanied by sudanophilia of the elastic fibers, where the calcification started, and by the presence of mucopolysaccharides between the fibers, as indicated by P.A.S. and alcian blue stains. Concurrent subcutaneous administration of condensed phosphates prevented the calcification as assessed by chemical determination of calcium and by silver nitrate staining. The development of the various matrix stains was inhibited as well. The most likely mechanism of this inhibition is thought to be the prevention of the formation of calcium phosphate crystals by the condensed phosphates. Possible mechanisms of the inhibition of the matrix changes are discussed.
We are grateful to Miss Isabelle Frossard and Miss Marianne Latscha for technical assistance.
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