Abstract
Summary
The inherited absence of an effective hemolytic complement system is linked with a deficiency in an antigen, MuBl, and constitutes an inborn error of metabolism. MuBl is completely lacking in animals of certain inbred strains of mice. The regulation of the concentration of MuBl as a function of age, of sex and of the number of gene copies per cell, was studied. The concentration of MuBl was identical in 3-week-old males and females. In older animals, it was approximately 1.5 times as high in the male as in the female. The concentration of the antigen was twice as great in homozygous as in heterozygous animals.
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