Abstract
Summary
Leucine-C14 was utilized to study the affects of 2 oral hypoglycemic agents (tol-butamide and phenethylbiguanide) on protein metabolism. Both compounds were seen to inhibit C14O2 production and incorporation of the amino acid into protein by rat liver ho-mogenate. Differences in the mode of inhibition are noted and discussed. Neither compound appears to be dependent on the presence of glucose for its in vitro affects on protein metabolism.
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