The in vitro Effect of Two Oral Hypoglycemic Agents on Hepatic Protein Synthesis. ∗

Abstract

Summary

Leucine-C¹⁴ was utilized to study the affects of 2 oral hypoglycemic agents (tol-butamide and phenethylbiguanide) on protein metabolism. Both compounds were seen to inhibit C¹⁴O₂ production and incorporation of the amino acid into protein by rat liver ho-mogenate. Differences in the mode of inhibition are noted and discussed. Neither compound appears to be dependent on the presence of glucose for its in vitro affects on protein metabolism.