Abstract
Summary
Pyrrolidinomethyl tetracycline was administered to rats, rabbits, and monkeys for 10 days and changes in the utilization of glucose and distribution of lipids in the tissues were studied. Treated animals showed diminished glucose tolerance. They had decreased glycogen and increased cholesterol and total lipids in the liver. There was a rise in plasma levels of lipids such as cholesterol, phospholipids, triglycerides and free fatty acids. Changes indicated impaired metabolism of carbohydrate and lipids. Tetracycline moiety of the antibiotic seemed responsible for the changes observed. The drug should be used with caution as its therapeutic effect might disturb the normal metabolic patterns in the body.
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