Abstract
Summary
Two series of unanesthetized rats were infused intraarterially with standardized volumes of 1.46 M (50% w/v) sucrose over the range 2.0 to 5.0 ml/100 g body weight. Animals in one of these series had been exposed 5 days earlier to the same concentration of sucrose at 2.0 ml/100 g body weight. These latter animals constituted the adapted groups. Comparison of the sucrose tolerance of adapted animals with nonadapted revealed that previous exposure to hypertonic sucrose significantly increased the resistance of twice-loaded animals to the damaging effects of the hypertonic solution. Evaluation of the excretion patterns of urinary solutes and the relationships between urine flow and solute concentrations suggest that a reduction in GFR may occur in nonadapted animals as load of hypertonic sucrose is increased from 2.0 to 4.5 ml/100 g b.w. Similar loads given to adapted animals appear less effective in their GFR depressing actions.
The authors gratefully acknowledge the excellent assistance of Mr. Don deSteiguer and Mr. Russell Moses.
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