Abstract
Summary
Studies of homologous disease in newborn mice using axenic and conventional animals (a) provide evidence that for the same dosage of cells, populations of spleen cells have different effects according to their origin. They are more efficient if donors are conventional or immunized axenic, and less efficient if the donors are only axenic. The basis for these differences has not been determined. (b) Provide no evidence that super-infection plays a role in the G.V.H. reaction in this short time system; (c) definitely separate homologous disease of newborn from similar syndromes induced by other investigators with experimental infectious agents.
The cooperation and help of Dr. G. A. Voisin and Dr. R. Kinsky are gratefully acknowledged. We also appreciate the invaluable technical assistance given by Mrs. A. Collard and Miss J. Deloupe.
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