Abstract
Summary
The effect of hypophysectomy upon the serum lipids was studied in rats in which nephrosis was produced by the amino-nucleoside of puromycin. Hypophysectomy prevented the usual rise of the serum cholesterol and triglyceride in the nephrotic rats. It is postulated that the hyperlipemia of nephrosis may result from enhanced lipoprotein synthesis in the liver from an effect of pituitary hormones. The hypophysectomized rats with nephrosis had higher blood urea nitrogen values and less proteinuria than did the nonhypophysectomized rats with nephrosis.
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