Abstract
Summary
Clonally derived adenovirus types 12 and 18 induced tumors in hamsters. Specific complement fixing antigens were demonstrated in the tumors, and the tumored hamsters developed specific complement fixing antibodies to both tumor and T antigens. The histologic characteristics of the tumors resembled those previously described for tumors induced by these viruses. These data support the conclusion that adenovirus types 12 and 18 can induce tumors in hamsters without the aid of other agents.
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