Abstract
Summary
A TRIG agent (LB-1), a member of the psittacosis-LGV-trachoma group, can induce the production in vivo and in vitro of a material with antiviral activity similar to virus-induced interferon. The interferon induced in cell culture by LB-1 had a molecular weight of about 50,000 and hence appeared to differ significantly from virus-induced interferon prepared in cell culture or in vivo.
Addendum: The peak of TRIC-induced interferon production in serum of mice is late (6-13 hours), similar to that of virus(3), brucella(3), or statalon(lO), but distinct from the early (2 hour) peak appearing after endotoxin(4).
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