Mechanism of Chlorpromazine-Induced Liver Nonprotein Sulfhydryl Depletion. ∗

Abstract

Summary and Conclusions

CPZ induced a depletion of LNPSH which differed significantly from control levels at 4 hours, but not at ½ 2, 8 and 20 hours after administration. The adrenal cortex, but not the hypophysis are integral components of the depleting mechanism. The release of epinephrine in the presence of corticosteroids may be the mediator of the CPZ-induced LNPSH depletion.