Abstract
Summary
Adult male rats were gonadec-tomized for 20 days. The mean DNA of their mammary glands was 3.59 ± 0.27 mg/100 g BW. Similar rats were injected for 20 days with 2 mg EB + 6 mg P/day. The mean DNA of their glands was 6.09 ± 0.33 mg/ 100 g BW, a significant increase over the control group and equal to the level of DNA induced by the same ovarian hormones in overiectomized female rats. A similar group of gonadectomized rats treated with EB + P for 20 days was then injected with 3 mg testosterone/day for 20 days. Testosterone was ineffective in preventing involution of the lobule-alveolar system of these animals as indicated by the mean DNA of 3.59 ± 0.004 mg/100 g BW, which is the same as the group prior to EB + P treatment.
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