Abstract
Summary
A substance has been detected in the throat washings of military recruits that is bactericidal for Groups A, B, and C. N. meningitidis, related Neisseriae, and other Gram-negative and Gram-positive bacteria. The inhibitor appears to be different in its chemical properties from previously reported bacterial inhibitors present in unstimulated saliva, The inhibitor has been characterized as a low molecular weight (5000 or less) substance which is dialyzable, resistant to prochemical properties from previously reported teolytic and lipolytic enzymes, Biuret-positive, and Molish-negative. Activity of the inhibitor against the meningococci was destroyed by heating at 100°C for one hour.
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