Abstract
Summary
The strains of adenovirus types 1 through 5 adapted to rhesus monkey kidney cultures for use in vaccines became contaminated with SV40 virus and formed hybrids, carrying SV40 genetic material in adenovirus capsids in a manner similar to that seen in Ad. 7 strain LLE46. The ability of the strains studied here to propagate in monkey cells (with the possible exception of type 5) is dependent on the SV40 genetic material and is not due to emergence of monkey-adapted adenovirus mutants.
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