Abstract
Summary
Gelatin markedly inhibited the uptake of colloidal gold by rat liver slices incubated in heparinized rat plasma. In contrast, the phagocytosis of albumin aggregates was affected only at high gelatin doses. Gelatin had no inhibitory effect on gold particles previously incubated with heparinized plasma. Plasma of mice, dogs, and rats enhanced uptake by the respective liver slice. Rabbit plasma failed to support phagocytosis by rabbit or rat liver slices; however, rat plasma facilitated phagocytosis by rabbit liver. It is suggested that rabbit plasma is deficient in a factor essential for in vitro hepatic phagocytosis. It is also indicated that gelatin interacts with plasma opsonin in rat plasma and thereby induces reticuloendothelial depression.
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