Efficacy of N 6 -(2-Hydroxyethyl)Adenine Against Coe Virus Infection In Mice

Abstract

Summary

The compound N⁶-(2-hydroxy-ethyl)adenine (HEA) was effective in favorably modifying experimental Coe virus infection in mice. HEA showed antiviral activity when a single injection, approximately one-tenth the lethal dose, was given from 24 hours before to 17 hours after virus inoculation. The toxicity, but not the antiviral activity of HEA, was partly reversed by simultaneous treatment with a xanthine oxidase inhibitor.