Abstract
Summary
1. Administration of 1.0 mg/day of cortisone to wounded female rats over a period of 12 days resulted in a weight loss significantly greater than that due to wounding and low protein diet alone. 2. Cortisone inhibited the formation of collagen. On the basis of tyrosine content, the sterol had no effect on the synthesis of total cellular proteins. 3. The rate of formation of cystine-rich proteins in the wound tissue was inhibited by the cortisone treatment. 4. The turnover of disulfide-bound cystine attached to the protein of the wound tissue cells was reduced in rats receiving cortisone, indicating a decreased utilization of cystine (or sulfhydryl) activated enzymes.
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