Influence of Adrenalectomy on Homologous Disease. ∗

Abstract

Summary

Adrenalectomy performed 24 hours before the induction of homologous disease, by the injection of parental strain spleen cells, resulted in early death in both (A X C57B1/1)F1 recipients of A spleen cells, and in (C3H X CS7B1/1)F1 recipients of C3H spleen cells. In addition there was an increased incidence of death in the latter strain combination. The early death of adre-nalectomized (C3H X C57B1/1)F1 recipients of C3H parental strain spleen cells was prevented by the administration of cortisone acetate.