Edema of the Skin and Menstruation in Monkeys {Macaca mulatto) On Repeated Estrogen Treatments. ∗

Abstract

Summary

The marked edematous effect of large doses of estrogen on the skin of monkeys decreases progressively on repeated treatments. The response finally attained is characterized by a general absence of edema though some growth and wrinkling of the skin may occur. A concomitant effect is a lengthening of the interval between discontinuance of an estrogen treatment and subsequent withdrawal bleeding, and in certain animals such bleeding may cease to occur. These conditions in the skin and uterus once established seem to persist indefinitely.