Abstract
Summary
Hamycin, a heptaene antifungal antibiotic, showed antiinflammatory activity in rats by oral and intraperitoneal route when tested against paw inflammations produced by egg albumin and formalin and against granuloma formation by subcutaneous implantation of cotton pellets. Hamycin showed marked catabolic, thymolytic and adrenotro-phic action. All these actions of hamycin are possibly mediated through a direct and prolonged stimulation of hypothalamus-hypo-physeal region of central nervous system resulting in prolonged liberation of ACTH.
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