Electron Microscopy of Monkey Liver After Exposure of Animals To Pure Oxygen Atmosphere. ∗

Abstract

Summary

Livers of monkeys exposed to pure oxygen at 380 mm Hg were examined electron microscopically. Only minimal nonspecific changes were observed; the most significant was an increase in smooth endoplas-mic reticulum at the expense of the rough form and glycogen. The changes, which appeared as early as 24 hours and were gone by 2 weeks, are considered an adaptive response rather than a sign of toxicity.