Abstract
Summary
An anticoagulant factor has been demonstrated in the extract of the sea anemone Rhodactis howesii. It is not related to the lethal “neuro”- toxin and the hemo-lysin which occur in that anemone. The factor is non-dialyzable. It is resistant to a pH of 2.0 and 10.5 in the cold, to autoclaving for 2 hours at 120°C under 15 lb pressure, and to treatment with acetone and chloroform. By the plasma recalcincation method 700 μg of the total dry organic material of the extract afford a 10-times prolongation of coagulation time as compared with 3.3 μg of heparin. Calcium deprivation as a possible mechanism, for the anticoagulant effect has been ruled out.
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