Studies on the Site and Rate of Replication of the GP Strain of Coxsackie B1 Virus in Mice

Abstract

Summary

The GP strain of Coxsackie B1 virus replicates rapidly and to high titers in the liver of infected mice. Smaller yields occur in the skeletal muscle and brain. Virus appears within 24 hours in the liver and in skeletal muscle but is not detected in the brain until 48 hours after infection. Signs of illness appear 72 hours after infection regardless of the infecting dose.