Two-Component Radiation Effect on Strontium 85 Absorption by The Rat Ileum in situ

Abstract

Summary

Male Wistar rats (150–180 g) were exposed to 0, 695, 926, and 1158 R whole body X-irradiation and tested for changes in Sr⁸⁵ absorption 1, 2, 3, and 4 days after irradiation by injecting a Sr⁸⁵ solution into ligated ileal sacs in situ and recovering the unabsorbed dose 3 hours later. A 2-component radiation effect was described. Two days after 695 R, the rats showed a significant decrease in absorption followed by a return to the control level within 2 more days. Three days after 926 R, there was a significant increase in Sr⁸⁵ absorption; those that survived to 4 days showed a trend back to the control level. Three days after 1158 R, there was a highly significant increase in absorption; no rats survived beyond 3 days.

Y⁹¹, which is not at all absorbed by the normal intestine, is also not absorbed by 695 R rats 2 days after irradiation or 1158 R rats 3 days after irradiation.