Abstract
Summary
We examined the inhibitory effects of fat in the proximal small intestine on secretion and motility in the gastrin-stimulated canine Heidenhain pouch. Relatively small amounts of fatty acid and monoglyceride in micellar form or much larger amounts of triglyceride in an emulsified state inhibited both motility and secretion in the pouch when introduced into the gut by way of the stomach. Duodenectomy reduced the inhibitory potency with respect to motility but not secretion. Perfusion of duodenal or jejunal loops with micellar fat was associated with a still smaller inhibitory effect on secretion and was without effect on motility.
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