Abstract
Summary
The I-antigen of rabbit and human A1I erythrocytes was found to be inactivated by a potent α-galactosidase, while its reactivity was not influenced by β-galactosidase. Experimentally produced rabbit cold agglutinins were inhibited by several α-galactosides or by incubation with heat killed L. monocytogenes, the antigen responsible for their production. However, α-galactosides did not inhibit the reactivity of two different human cold agglutinins with anti-I specificity. The differences between the reactivity of human and rabbit cold agglutinins could be ascribed to differences in the structure of the antibody combining site.
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