Abstract
Summary
U-10387 (S-carboxy-3-methyl-isoxazole) was shown to increase glucose-1-C14 oxidation and depress release of FFA by adipose tissue in vitro and depress blood sugar of eviscerate rats. Since 3,5-dimethylisoxazole was inactive on these parameters but did lower FFA and blood sugar of intact rats, it was suggested that the activity of the 3,5-dimethyl compound was due to metabolism to the 5-carboxy derivative. Both compounds were equipotent in the intact animal in lowering FFA and blood sugar. Activities of 5-carboxy-3-methylisoxazole on the fat pad and eviscerate rats are effects similar to those exhibited by insulin.
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