Abstract
Summary
Rats with chronic PHH hemolysis developed severe anemia and marked increase in red cell size following splenectomy. The macrocytosis could not be explained by decreased destruction of macrocytes in splenectomized animals. The increased red cell size following splenectomy is believed to result from curtailment of the capability for compensatory expansion of erythropoiesis with a resulting increased stimulus per unit volume of remaining erythropoietic tissue. The macrocytosis sometimes seen in human myelofibrosis may be similarly explained.
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