Abstract
Summary
The antigenic relationships of the ECHO-28 strains and B632 were studied in guinea pigs. The cross reaction demonstrated between B632 and JH was reciprocal, while the one between B632 and 2060 was not. Inoculation of guinea pigs with both B632 and 2060 virus in different order brought out the antigenic relationship of these types. In human sera, the age-specific prevalence of ECHO-28 and B632 antibody was compared. A titer rise to one or both types was found in 41 of 355 paired sera. This increase in antibody occurred in some cases in spite of homologous prior antibody. In most cases, the rises in antibody level occurred against only one virus, but there was a strong suggestion that with prior antibody, an increase in antibody to both viruses was more likely.
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