In vitro Inhibition of Leukocyte Uptake of Radioactive Endotoxin by Components of Normal Serum. ∗

Abstract

Summary

Chromium⁵¹-labeled enterobacterial lipopolysaccharides were incubated with leukocytes or erythrocytes in the presence or absence of serum (or serum protein components) . Leukocytes exhibit a much greater affinity for endotoxin than erythrocytes. Serum inhibits the rate of uptake of lipopolysaccharide by the blood cells. Each of the serum fractions (albumin, and α₁-, α₂-, β-, γ-globulins) interfere in the uptake of endotoxin by leukocytes.