Abstract
Summary
Three well-known amebicides, carbarsone, emetine and glaucarubin were tested against Acanthamoeba sp., a small free-living soil amoeba. The drugs have an initial lethal effect followed by a lesser inhibition of growth rate. On a molar basis, carbarsone is the most effective agent against Acanthamoeba. The results support the contention that emetine is more potent against the pathogenic E. histolytica than against free-living amoebae, whereas, carbarsone has similar inhibitory effects on the two types. Glaucarubin, although the least effective against Acanthamoeba on a molar basis is most effective when compared to the amebicidal endpoint doses on pathogenic amoebae.
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