Abstract
Summary
Liver glycogen phosphorylase activity was studied in mice at early times subsequent to in vivo administration of puromycin, and following puromycin addition to incubations of rat liver slices. No effect of puromycin on phosphorylase could be detected following injection of unanesthetized mice. Puromycin treatment of pentobarbital-anesthetized mice, however, resulted in an enhancement of the phosphorylase activity as compared to control values. Phosphorylase activity in rat liver slices incubated with puromycin was greater than those incubated without puromycin. These results indicate that puromycin can elevate liver phosphorylase activity, a finding consistent with the hepatic glycogenolytic action of the antibiotic in vivo.
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