Abstract
Summary
In the rat, addition of methionine to a high-fat low-protein diet markedly prevented the production of thrombotic and atherosclerotic lesions and the hypercholesterolemia normally induced by such dietary feeding. This marked protective effect of methionine could not be reproduced by other amino acids, such as tryptophan, histidine and cystine, or by choline. Combined addition to the diet of cystine and choline afforded some protection, but was not as effective as methionine.
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