Abstract
Summary
A total of 38 neoplastic tissue preparations from a variety of human cancers were tested for presence of a tumor-inducing principle in newborn ICR/Ha mice. The mice were sex-segregated to prevent pregnancy and to limit occurrence of spontaneous mammary carcinoma. The malignant tissue specimens were tested as crude extracts, after fluorocarbon extraction, or following treatment by the Burton-Friedman method which was reported to make possible tumor induction in mice. There was no evidence for a tumor-inducing principle in any of the specimens tested. Numerous spontaneous neoplasias were observed and mammary carcinoma and malignant lymphoma were most commonly present.
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