Abstract
Summary
The immunoelectrophoretic patterns of the gamma globulins were studied in the sera of Thai patients infected with Vibrio cholerae, Ogawa type. Normal Thai sera and sera obtained from Japanese vaccinees were used as controls. Relations were sought between the protein patterns, and the agglutinin titers as well as the cholera toxigenicity neutralizing ability (CTNA) of the sera. The immunologic response to cholera infection was similar to that in other bacterial diseases. A higher CTNA was noted in natural infection than after vaccination. As a group, the cholera patients had a high incidence of γ-M-globulin in sera taken in the acute phases of the disease. It is suggested that this might be due either to a rapid increase of this globulin or to the presence of concomitant and/or chronic disease.
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