Urinary Excretion of Ingested α-Aminoisobutyric Acid-N 15 in Dogs Treated with Growth Hormone or Corticotropin. ∗

Abstract

Summary

The rate of urinary excretion of ingested α-aminoisobutyric acid-N¹⁵ (AIB) was determined in dogs, in control experiments and during treatment with growth hormone or corticotropin. Growth hormone had only a slight effect, while corticotropin increased the rate of excretion somewhat, particularly during the second 6-hour period after ingestion. Apparently changes in absorption, distribution, and excretion play only a minor role in growth hormone action, while corticotropin directly affects one or more of these processes in addition to its effects on protein metabolism and gluconeogenesis. None of the N¹⁵ ingested as AIB appeared in urinary urea or ammonia.