Abstract
Summary
The rate of urinary excretion of ingested α-aminoisobutyric acid-N15 (AIB) was determined in dogs, in control experiments and during treatment with growth hormone or corticotropin. Growth hormone had only a slight effect, while corticotropin increased the rate of excretion somewhat, particularly during the second 6-hour period after ingestion. Apparently changes in absorption, distribution, and excretion play only a minor role in growth hormone action, while corticotropin directly affects one or more of these processes in addition to its effects on protein metabolism and gluconeogenesis. None of the N15 ingested as AIB appeared in urinary urea or ammonia.
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