Abstract
Summary
Mithramycin in concentrations of 1.0–100 μg/ml prevented the multiplication of the DNA viruses, pseudorabies and murine cytomegalovirus, but not the RNA viruses, encephalomyocarditis and polio, in tissue culture. The inhibition was fully reversible by removing the mithramycin early in the virus growth cycle. With removal of the drug at a later state, there was delayed emergence of new virus. The data suggest that mithramycin reversibly inhibits the synthesis of viral DNA-directed RNA.
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