Abstract
Summary
Three hours following unilateral nephrectomy weanling female CF-1 mice were subjected to local abdominal or total body exposure to either 500 or 600 r. Other groups were given 1350 r to half the abdomen with and without prior nephrectomy. Significant decreases in renal weight gain compared to controls were obtained in the 600 r total body group and in the locally irradiated animals given 1350 r. When the renal weight changes are compared on the basis of the ratio of renal weight to body weight in per cent, an increase from .64% to .95% is seen in animals subjected to nephrectomy alone. The final value in all of the irradiated and nephrectomized groups was similar, ranging from .93% to 1.0%. The results suggest that irradiation in these dose ranges does not exert a direct inhibitory effect on renal weight increase but it limits body weight gain which influences kidney weight.
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