Abstract
Summary
It has been shown that FU, at a 10-3 concentration, markedly inhibits DNA synthesis in DK cells infected with ICHV. In the absence of FU, DNA levels in infected cells increased to about 450% of uninfected control cell levels by 72 hours postinfection. By contrast, the marked elevation of nuclear and cytoplasmic arginine levels (an index of protein levels) that is seen in infected cells was not affected by the presence of FU. No infectious virus particles were formed in the presence of FU. Electron microscopic examination of infected, FU-treated cells did not reveal the presence of either complete virus particles or empty viral capsids. However, these cells produced hemagglutinins and also virus specific antigen demonstrable by immunofluorescence.
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