Abstract
Summary
Changes in degree of granularity of juxtaglomerular cells (JGI) and width of zona glomerulosa of adrenal cortices (ZGI) of adult Wistar rats subjected to dietary restriction of sodium or salt overload was encountered only when these regimens were supplemented by peritoneal dialysis or administration of DCA, respectively. Increase in these parameters following the former and decrease after the latter both exhibited delay in onset as well as their recovery to control values following sodium repletion or cessation of salt overloading. Decrease in JGI and ZGI occurred prior to the onset of hypertension in rats receiving DCA and saline. These findings are consonant with views concerning the “endocrine” nature of JGC as well as their role as osmoreceptors.
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