Abstract
Summary
A series of reference and experimental estrogens has been evaluated in terms of the amount required to reduce total serum cholesterol 33% in mature male rats and the amount required to increase the uterine weights of weanling female rats 50 mg over those of the controls. The resultant hypocholesteremic: uterotrophic dissociations were: estrone 50, Premarin® 20, estrone methyl ether >3.2, 16α-chloroestrone methyl ether 2.4, 17-(4-hydroxy-1-butynyl)-3-methoxyestra-1,3,5 (10)-trien-17β-ol 1.6, 17-(3-hydroxypropyl)-3-methoxyestra-1,3,5 (10)-trien-17β-ol 0.2, and 17-(3-hydroxy-1-propynyl)-3-methoxyestra-1,3,5 (10) -trien-17β-ol 17α-hydrocinnamate 0.015. The hydroxy propynyl compound thus has the best dissociation of any steroid noted.
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