Abstract
Summary
Glutamic-oxaloacetic-transaminase (GOT) and glutamic-pyruvic-transaminase (GPT) of serum, aorta and liver and free amino acid composition of the serum and aorta were determined in normal and hypercholesteremic-atherosclerotic chickens. GOT and GPT of serum and GOT of liver increased with the onset of atherosclerosis suggesting an overall increase in the rate of transamination reaction in the body. The activities of the arterial transaminases did not change appreciably. Concentrations of most of the free amino acids increased in the serum and diminished in the aorta of hyper-cholesteremic-atherosclerotic chickens. Chemical changes accompany the morphological alterations during the progress of atherosclerosis.
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