Abstract
Summary
2,8-Dichloro-6,12-diphenyl-dibenzo[b,f][l,5] diazocine completely inhibited pregnancy when administered either orally or subcutaneously to female rats at doses as low as 0.5 mg daily for 7 days at time of mating. At higher doses, single treatments prior to completion of implantation were equally effective. Systemic or fetal toxicity did not occur at therapeutic doses. This compound also induced uterine growth, vaginal cornification, blastocyst implantation and inhibited gonadotropin activity. Each of these latter effects are indicative of estrogenic properties, and are probably involved with antifertility efficacy. This non-steroidal compound is a structurally unique addition to those agents with these biological activities.
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