Abstract
Summary
In rats made hypertensive by clipping a renal artery or subcutaneous renin injections, removal of the clipped kidney or cessation of renin administration were followed by an abrupt fall in arterial pressure, which stabilized at a level higher than the control value. This was associated with healing of mesenteric arteritis, while hyaline lesions remained unaffected. The functional and pathologic changes caused by removal of the clip were prevented by administration of renin. These experiments provide additional evidence that renal and renin-induced hypertension may have the same pathogenesis.
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